TAG/TIRAP3/TICAM2 is a member of the Toll/Interleukin 1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). It undergoes post-translational modifications such as myristoylation and phosphorylation. TAG is a homodimer interacting with TLR4, TICAM1, IRF3 and IRF7 in response to LPS activation. The LPS-TLR4 signaling cascade regulates the MYD88-independent pathway during innate immune response. It is also involved in IL-1 triggered NF-kappa-B activation. It physically binds TLR4 and TICAM1 to transmit LPS-TLR4 signal to TICAM. Expression of TIRAP3 appears to be essential for TLR4 signaling.
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Protein Aliases: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TIRAP3; TIRP; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Gene Aliases: B430113A10; BOS_10068; MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM; Trif