Peptide sequence: FRLREAQGRS RAEDLNTRVA YWHSVDTSPG YHESDSKKSE DLSLCNVAEH
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway.
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Protein Aliases: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; TIRAP3; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; Transmembrane emp24 protein transport domain containing 7; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Gene Aliases: B430113A10; BOS_10068; MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM; Trif