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TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
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Protein Aliases: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Gene Aliases: B430113A10; MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM; Trif
UniProt ID: (Human) Q86XR7, (Mouse) Q8BJQ4
Entrez Gene ID: (Human) 353376, (Mouse) 225471, (Rat) 364867
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