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Proteintech
TID1 Polyclonal Antibody
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Product Details
11088-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TID1 Fusion Protein Ag1558 (181-480 aa encoded by BC011855)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DPEELFRKI FGEFSSSSFG DFQTVFDQPQ EYFMELTFNQ AAKGVNKEFT VNIMDTCERC NGKGNEPGTK VQHCHYCGGS GMETINTGPF VMRSTCRRCG GRGSIIISPC VVCRGAGQAK QKKRVMIPVP AGVEDGQTVR MPVGKREIFI TFRVQKSPVF RRDGADIHSD LFISIAQALL GGTARAQGLY ETINVTIPPG TQTDQKIRMG GKGIPRINSY GYGDHYIHIK IRVPKRLTSR QQSLILSYAE DETDVEGTVN GVTLTSSGGS TMDSSAGSKA RREAGEDEEG FLSKLKKMFT S (181-480 aa encoded by BC011855)
Target Information
TID1 is a human homolog of the Drosophila tumor suppressor lethal (2) tumorous imaginal discs, l(2)tid and encodes two mitochondrial matrix localized splice variants of human Tid-1 designated hTid-1S and hTid-1L. These proteins are the conserved members of the DnaJ family of proteins which act as cochaperones for mitochondrial Hsp70. They contain a conserved tetrahedrical J domain which binds to Hsp70 chaperones and activates their ATPase activity. Expression of hTid-1L increases apoptosis induced by DNA damaging agents as mitomycin-C and TNF-a. A J-domain mutant of hTid-1L can dominantly suppress apoptosis and in sharp contrast the J-domain mutant of hTid-1S increases apoptosis. Expression of hTid-1S and hTid-1L affects cytochrome c release from the mitochondria and caspase 3 activation, while activation of caspase 8 is unaffected. It is strongly suggested that these two splice variants exert their anti- and pro- apoptotic effects through discrete substrates and activities. Hence the relative abundance of these proteins or their substrates may allow the mitochondria to dampen or enhance the apoptotic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DnaJ (Hsp40) homolog, subfamily A, member 3; DnaJ homolog subfamily A member 3, mitochondrial; DnaJ protein Tid-1; Hepatocellular carcinoma-associated antigen 57; hTid-1; hTid-1 protein; mTid-1; Tumorous imaginal discs protein Tid56 homolog; unnamed protein product
Gene Aliases: 1200003J13Rik; 1810053A11Rik; C81173; DNAJA3; HCA57; hTID-1; Tid-1; TID1; Tid1-L; Tid1-S; Tid1l
UniProt ID: (Human) Q96EY1, (Mouse) Q99M87
Entrez Gene ID: (Human) 9093, (Mouse) 83945, (Rat) 360481
receptor binding
interferon-gamma receptor binding
protein binding
ATP binding
zinc ion binding
protein kinase binding
Hsp70 protein binding
GTPase regulator activity
heat shock protein binding
macromolecular complex binding
metal ion binding
NF-kappaB binding
unfolded protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
IkappaB kinase complex binding
DNA-binding transcription factor binding
transcription factor binding
receptor tyrosine kinase binding
chaperone binding
chaperone
negative regulation of transcription from RNA polymerase II promoter
immune system process
regulation of immune system process
mitochondrial DNA replication
protein folding
apoptotic process
activation-induced cell death of T cells
response to stress
mitochondrion organization
small GTPase mediated signal transduction
neuromuscular junction development
negative regulation of cell proliferation
response to heat
positive regulation of protein ubiquitination
T cell differentiation in thymus
response to interferon-gamma
positive regulation of T cell proliferation
regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein stabilization
negative regulation of interferon-gamma-mediated signaling pathway
skeletal muscle acetylcholine-gated channel clustering
cellular senescence
negative regulation of protein kinase activity
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell aging
embryo development
negative regulation of NF-kappaB transcription factor activity
protein refolding
regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of catalytic activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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