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Invitrogen
TIGAR Polyclonal Antibody
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Product Details
PA5-20347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide from near the center of human TIGAR.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is MCF7 cell lysate.
PA5-20347 can be used with blocking peptide PEP-0467.
Target Information
This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fructose-2,6-bisphosphatase TIGAR; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase; transactivated by NS3TP2 protein
Gene Aliases: 9630033F20Rik; AA793651; AI595337; C12orf5; C79710; C85509; FR2BP; TIGAR
UniProt ID: (Human) Q9NQ88, (Mouse) Q8BZA9
Entrez Gene ID: (Human) 57103, (Mouse) 319801
response to ischemia
fructose 2,6-bisphosphate metabolic process
autophagy
apoptotic process
cellular response to DNA damage stimulus
response to xenobiotic stimulus
response to gamma radiation
positive regulation of cardiac muscle cell apoptotic process
dephosphorylation
fructose 1,6-bisphosphate metabolic process
negative regulation of programmed cell death
regulation of pentose-phosphate shunt
positive regulation of DNA repair
negative regulation of glycolytic process
intestinal epithelial cell development
cellular response to cobalt ion
cellular response to hypoxia
negative regulation of neuron death
negative regulation of macromitophagy
regulation of response to DNA damage checkpoint signaling
positive regulation of hexokinase activity
negative regulation of glucose catabolic process to lactate via pyruvate
negative regulation of reactive oxygen species metabolic process
metabolic process
negative regulation of kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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