This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
PA5-29151 targets TIGAR in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29151 immunogen is synthetic peptide corresponding to a region within amino acids 206 and 270 of Human TIGAR.
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This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.
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Protein Aliases: 6-bisphosphatase TIGAR; Fructose-2,6-bisphosphatase TIGAR; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2; probable fructose-2,6-bisphosphatase TIGAR; TIGAR; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase; transactivated by NS3TP2 protein
Gene Aliases: C12orf5; FR2BP; TIGAR
UniProt ID: (Human) Q9NQ88
Entrez Gene ID: (Human) 57103