Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: SETVVTEVL GHRVTLPCLY SSWSHNSNSM CWGKDQCPYS GCKEALIRTD GMRVTSRKSA KYRLQGTIPR GDVSLTILNP SESDSGVYCC RIEVPGWFND VKINVRLNLQ RASTTTHRTA TTTTRRTTTT SPTTTRQMTT TPAALPTTVV TTPDLTTGTP LQMTTIAVFT TANTCLSLTP STLPEEATGL LTPEPSKEGP ILTAESETVL PSDSWSSAES TSADTVLLTS KESKVWDLPS TSHVSMWKTS DSVSSPQPGA SDTAVPEQNK TTKTGQMDGI PMSMKNEMPI SQLLMIIAPS LGFVLFALFV AFLLRGKLME TYCSQKHTRL DYIGDSKNVL NDVQHGREDE DGLFTL (24-378 aa encoded by BC008988)
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
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