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AbboMax
TIMP-4 Polyclonal Antibody
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FIGURE: 1 / 1
TIMP-4 Antibody (630-190ABBOMAX) in WB
Western Blot: The cell lysate derived from astrocytoma (SW-1783) was resolved onto 12% SDS-PAGE, transferred onto NC membrane, and immunoprobed by Rabbit anti-TIMP-4 (Cat#630-190) at 1:500. An immunoreactive band is observed around ~25 kDa (1). This band is abolished by pre-incubation with immunizing peptide (2).
Product Details
630-190ABBOMAX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to C-term of human TIMP-4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Gliomas
Cellular location: Cytoplasmic, extracellular matrix.
Target Information
Tissue inhibitor of metalloproteinase 4 (TIMP4) is encoded by the gene TIMP4 located on chromosome 3. It belongs to the family of TIMP genes and is known to inhibit the activity of matrix metalloproteinases. Matrix metalloproteinases (MMP) are a group of proteinases that degrade the components of extracellular matrix. TIMP4 irreversibly binds to MMPs and inactivates them with the help of zinc as a cofactor. The netrin domain of TIMP4 is involved in platelet recruitment and aggregation. Other biological functions include response to cytokine and peptide hormone stimuli and involvement with the ovulation cycle and CNS development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Metalloproteinase inhibitor 4; TIMP 4; TIMP-4; TIMP4; tissue inhibitor of metalloproteinase; tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4; unnamed protein product
Gene Aliases: TIMP-4; TIMP4
UniProt ID: (Bovine) O97563, (Human) Q99727, (Mouse) Q9JHB3, (Rat) P81556
Entrez Gene ID: (Bovine) 317694, (Human) 7079, (Mouse) 110595, (Rat) 680130
negative regulation of endopeptidase activity
Notch signaling pathway
response to hormone
response to cytokine
negative regulation of membrane protein ectodomain proteolysis
negative regulation of peptidase activity
negative regulation of catalytic activity
central nervous system development
response to lipopolysaccharide
response to drug
ovulation cycle
response to peptide hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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