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TIMP2 Polyclonal Antibody
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FIGURE: 1 / 2
TIMP2 Antibody (PA1-25313) in WB
Western blot was performed using Anti-TIMP2 Polyclonal Antibody (Product # PA1-25313) and a 22kDa band corresponding to TIMP2 was observed across cell lines tested except for Daudi which is reported to be negative. Whole cell extracts (30 µg lysate) of SH-SY5Y (Lane 1), SH-SY5Y treated with Protein Transport Inhibitor (1x for 4 hours) (Lane 2), HT-1080 (Lane 3), HT-1080 treated with Protein Transport Inhibitor (1x for 4 hours) (Lane 4), Daudi (Lane 5) and Daudi treated with Protein Transport Inhibitor (1x for 4 hours) were electrophoresed ... View More
Product Details
PA1-25313
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the first loop of human tissue inhibitor of metalloproteinase-2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Does not cross react with other TIMP family members (TIMP1, TIMP3, TIMP4).
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CSC-21K; Metalloproteinase inhibitor 2; metalloproteinase inhibitor precursor; metalloproteinase-2 inhibitor precursor; testicular secretory protein Li 57; TIMP 2; TIMP-2; Tissue inhibitor of metalloproteinases 2; unnamed protein product
Gene Aliases: CSC-21K; DDC8; TIMP2
UniProt ID: (Human) P16035
Entrez Gene ID: (Human) 7077
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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