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Invitrogen
TIMP2 Polyclonal Antibody
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FIGURE: 1 / 1
TIMP2 Antibody (PA5-86216) in WB
Western blot analysis of TIMP2 in Lane 1: HeLa whole cell lysate (40 µg), Lane 2: HEK293T whole cell lysate (40 µg), Lane 3: lung tissue lysate of mouse (40 µg), Lane 4: lung tissue lysate of rat (40 µg), Lane 5: placenta tissue lysate of rat (40 µg). Sample was incubated with TIMP2 polyclonal antibody (Product # PA5-86216) using a 1:500 dilution.
Product Details
PA5-86216
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 10-60 of Human TIMP-2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSC-21K; Metalloproteinase inhibitor 2; metalloproteinase inhibitor precursor; metalloproteinase-2 inhibitor precursor; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2; unnamed protein product
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2
UniProt ID: (Human) P16035, (Rat) P30121
Entrez Gene ID: (Human) 7077, (Rat) 29543, (Mouse) 21858
response to hormone
response to cytokine
negative regulation of membrane protein ectodomain proteolysis
negative regulation of metallopeptidase activity
spermatogenesis
central nervous system development
aging
negative regulation of cell proliferation
negative regulation of endopeptidase activity
regulation of cAMP metabolic process
regulation of Rap protein signal transduction
response to drug
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of proteolysis
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
cellular response to organic substance
negative regulation of peptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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