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Invitrogen
TIMP2 Polyclonal Antibody
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FIGURE: 1 / 1
TIMP2 Antibody (PA5-95330) in WB
Western blot analysis of TIMP2 in Lane 1: rat spleen tissue lysate (50 µg), Lane 2: rat testis tissue lysate (50 µg), Lane 3: mouse brain tissue lysate (50 µg), Lane 4: mouse thymus tissue lysate (50 µg), Lane 5: HeLa whole cell lysate (40 µg). Samples were incubated with TIMP2 polyclonal antibody (Product # PA5-95330).
Product Details
PA5-95330
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TIMP2 recombinant protein (Position: C27-P220).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse and rat TIMP2.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Spleen Tissue, Rat Testis Tissue, Mouse Brain Tissue, Mouse Thymus Tissue, HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CSC-21K; Metalloproteinase inhibitor 2; testicular secretory protein Li 57; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; Tissue inhibitor of metalloproteinases 2
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2; TIMP2
UniProt ID: (Human) P16035, (Rat) P30121
Entrez Gene ID: (Human) 7077, (Rat) 29543, (Mouse) 21858
central nervous system development
aging
negative regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
extracellular matrix disassembly
regulation of Rap protein signal transduction
response to cytokine
response to drug
positive regulation of MAPK cascade
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
negative regulation of membrane protein ectodomain proteolysis
spermatogenesis
regulation of cAMP metabolic process
positive regulation of catalytic activity
negative regulation of catalytic activity
regulation of MAPK cascade
regulation of neuron differentiation
negative regulation of proteolysis
cellular response to organic substance
negative regulation of peptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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