|Tested species reactivity||Human, Non-human primate, Rabbit|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptidecorresponding to the C-terminal portion of human TIMP-3.|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Ready-to-use|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21146 detects TIMP-3 in rabbit, human and baboon samples. This antibody will not detect rat, bovine, avian, or porcine samples.
PA1-21146 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-21146 immunogen is a synthetic peptidecorresponding to the C-terminal portion of human TIMP-3.
The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tightly bound inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.