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PA1-21146 detects TIMP-3 in rabbit, human and baboon samples. This antibody will not detect rat, bovine, avian, or porcine samples.
PA1-21146 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-21146 immunogen is a synthetic peptidecorresponding to the C-terminal portion of human TIMP-3.
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It functions to inhibit the activity of matrix metalloproteinases (MMP) which degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation. It binds irreversibly to zinc-dependent MMPs and inactivates them by binding to their catalytic zinc cofactor. Other functions of TIMP3 include nervous system development, tissue regeneration, and visual perception. In humans, the gene encoding TIMP3 is located on chromosome 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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