This antibody is predicted to react with rabbit and baboon based on sequence homology.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is placenta or breast carcinoma.
TIMPs (Tissue Inhibitors of MetalloProteinases) form tight inhibitory complexes with MMPs which are involved in matrix degradation and hence, in tumor invasiveness and metastasis. TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
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Protein Aliases: HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; MIG-5 protein; Protein MIG-5; SFD; TIMP-3; Tissue inhibitor of metalloproteinases 3
Gene Aliases: HSMRK222; K222; K222TA2; SFD; TIMP3
UniProt ID: (Human) P35625
Entrez Gene ID: (Human) 7078