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Invitrogen
TIMP3 Polyclonal Antibody
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FIGURE: 1 / 2
TIMP3 Antibody (PA5-78423) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of TIMP3 was performed in DIV10 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: TIMP3 Polyclonal Antibody (Product # PA5-78423) diluted at 1:500. Red: alpha Tubulin, stained by alpha Tubulin antibody. Blue: Fluoroshield with DAPI.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78423
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TIMP3. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.51 mg/mL
Amount
51 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: mouse kidney
Predicted Reactivity: Human (100%), Rat (97%), Xenopus laevis (83%), Dog (100%), Rabbit (97%), Chicken (82%), Sheep (100%), Rhesus Monkey (100%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It functions to inhibit the activity of matrix metalloproteinases (MMP) which degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation. It binds irreversibly to zinc-dependent MMPs and inactivates them by binding to their catalytic zinc cofactor. Other functions of TIMP3 include nervous system development, tissue regeneration, and visual perception. In humans, the gene encoding TIMP3 is located on chromosome 22.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MIG-5 protein; protein MIG-5; TIMP 3; TIMP-3; TIMP3; tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinases 3; tissue inhibitor of metalloproteinases-3; unnamed protein product
Gene Aliases: HSMRK222; K222; K222TA2; SFD; Timp-3
UniProt ID: (Human) P35625, (Mouse) P39876
Entrez Gene ID: (Human) 7078, (Rat) 25358, (Mouse) 21859
response to mechanical stimulus
response to hormone
negative regulation of extracellular matrix disassembly
response to muscle activity
response to nutrient levels
response to cytokine
tissue regeneration
response to amino acid
negative regulation of proteolysis
negative regulation of membrane protein ectodomain proteolysis
response to folic acid
cellular response to interleukin-6
cellular response to hypoxia
cellular response to peptide
mesenchymal cell differentiation involved in bone development
negative regulation of vascular smooth muscle cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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