PA1-24473 detects CC3 (HTATIP2) in Human samples.
PA1-24473 has been successfully used in Western Blot and immunohistochemistry (paraffin) procedures. While diluting for Western blot, use a 5% skim milk/PBS buffer solution.
PA1-24473 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human HTATIP2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
CC3 (HTATIP2) is a member of the short-chain dehydrogenases/reductases (SDR) family. It is a novel serine/threonine kinase that phosphorylates the C-terminal domain (CTD) of the largest RNA polymerase II subunit and induces the expression of apoptosis related genes Bad and Siva, as well as metastasis suppressor NM23-H2. It also interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates ERalpha-mediated c-myc transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 30 kDa HIV-1 TAT-interacting protein; CC3; HIV-1 tat interactive protein 2; HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 Tat interactive protein 2, 30kDa; HIV-1 TAT-interactive protein 2; HTATIP2; Oxidoreductase HTATIP2; short chain dehydrogenase/reductase family 44U, member 1; Tat-interacting protein (30kD); tat-interacting protein 30 kDa
Gene Aliases: AW111545; CC3; HTATIP2; SDR44U1; TIP30