PA5-27109 targets TIP30 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27109 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 242 of Human TIP30.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
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Protein Aliases: 30 kDa HIV-1 TAT-interacting protein; CC3; HIV-1 tat interactive protein 2, 30 kDa homolog; HIV-1 Tat interactive protein 2, 30kDa; HIV-1 TAT-interactive protein 2; HTATIP2; member 1; Oxidoreductase HTATIP2; SDR44U1; short chain dehydrogenase/reductase family 44U; short chain dehydrogenase/reductase family 44U, member 1; Tat-interacting protein (30kD); tat-interacting protein 30 kDa; TIP30
Gene Aliases: AW111545; CC3; HTATIP2; SDR44U1; TIP30