Immunogen sequence: GAEGFVRVDR DYVLKSAELA KAGGCKHFNL LSSKGADKSS NFLYLQVKGE VEAKVEELKF DRYSVFRPGV LLCDRQESRP GEWLVRKFFG SLPDSWASGH SVPVVTVVRA MLNNVVRPRD KQMELLENKA IHDLGKAHGS LKP; Positive Samples: LO2; Cellular Location: Cytoplasm, Nucleus envelope
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR- delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. In mice, mutations in the gene encoding GluR- delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR- delta2 maps to chromosome 4q22.
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Protein Aliases: 30 kDa HIV-1 TAT-interacting protein; HIV-1 Tat interactive protein 2, 30kDa; HIV-1 TAT-interactive protein 2; HTATIP2; Oxidoreductase HTATIP2; short chain dehydrogenase/reductase family 44U, member 1; Tat-interacting protein (30kD)
Gene Aliases: CC3; HTATIP2; SDR44U1; TIP30
UniProt ID: (Human) Q9BUP3
Entrez Gene ID: (Human) 10553