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Proteintech
TIP47 Polyclonal Antibody
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FIGURE: 1 / 13
TIP47 Antibody (10694-1-AP) in ICC/IF
Immunofluorescent analysis of (-20°C Ethanol) fixed oleic acid treated HeLa cells using TIP47 antibody (Product # 10694-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). F-actin was stained with CL594-phalloidin.
Product Details
10694-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TIP47 Fusion Protein Ag1028 (134-434 aa encoded by BC007566)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EMVSSAKDT VATQLSEAVD ATRGAVQSGV DKTKSVVTGG VQSVMGSRLG QMVLSGVDTV LGKSEEWADN HLPLTDAELA RIATSLDGFD VASVQQQRQE QSYFVRLGSL SERLRQHAYE HSLGKLRATK QRAQEALLQL SQALSLMETV KQGVDQKLVE GQEKLHQMWL SWNQKQLQGP EKEPPKPEQV ESRALTMFRD IAQQLQATCT SLGSSIQGLP TNVKDQVQQA RRQVEDLQAT FSSIHSFQDL SSSILAQSRE RVASAREALD HMVEYVAQNT PVTWLVGPFA PGITEKAPEE KK (134-434 aa encoded by BC007566)
Target Information
TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; mannose-6-phosphate receptor binding protein 1; Mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; Perilipin-3; Placental protein 17; PP17; tail-interacting protein, 47 kD; testicular tissue protein Li 114
Gene Aliases: 1300012C15Rik; M6PRBP1; PLIN3; PP17; TIP47
UniProt ID: (Human) O60664, (Mouse) Q9DBG5
Entrez Gene ID: (Human) 10226, (Mouse) 66905
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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