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TIP47 Polyclonal Antibody
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FIGURE: 1 / 2
TIP47 Antibody (600-401-FF2) in IHC (P)
Immunohistochemistry of TIP47 antibody. Tissue: rat liver tissue. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: TIP47 antibody at 2 µg/mL for 1 hr at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: TIP47 is located in the cell membrane. Staining: TIP47 is stained with hematoxylin purple nuclear counters... View More
Product Details
600-401-FF2
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-TIP47 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human TIP47.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome to Golgi transport. This protein also binds directly to the GTPase RAB9, a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; mannose-6-phosphate receptor binding protein 1; Mannose-6-phosphate receptor-binding protein 1; MGC11117; MGC2012; perilipin 3; Perilipin-3; Placental protein 17; PP17; soluble placental tissue protein; tail-interacting protein, 47 kD; testicular tissue protein Li 114; unnamed protein product
Gene Aliases: 1300012C15Rik; M6PRBP1; PLIN3; PP17; TIP47
UniProt ID: (Human) O60664, (Mouse) Q9DBG5
Entrez Gene ID: (Human) 10226, (Mouse) 66905, (Rat) 316130
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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