PA5-29457 targets TIP60 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-29457 immunogen is recombinant fragment corresponding to a region within amino acids 230 and 492 of Human TIP60.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
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Protein Aliases: 60 kDa Tat-interactive protein; 60kDa; cPLA(2)-interacting protein; cPLA2 interacting protein; ESA1; Histone acetyltransferase HTATIP; Histone acetyltransferase KAT5; HIV-1 Tat interactive protein; HIV-1 tat interactive protein 1, 60 kDa homolog; HIV-1 tat interactive protein 1, homolog; HIV-1 Tat interactive protein, 60kDa; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; K-acetyltransferase 5; lysine acetyltra; Lysine acetyltransferase 5; PLIP; Tat interacting protein; Tat interacting protein, 60kDa; Tat-interactive protein-60; TIP60
Gene Aliases: AI839539; CPLA2; ESA1; HTATIP; HTATIP1; KAT5; PLIP; TIP; Tip55; TIP60; ZC2HC5