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Invitrogen
TIPARP Polyclonal Antibody
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FIGURE: 1 / 4
TIPARP Antibody (PA5-98589) in IHC (P)
Immunohistochemical analysis of TIPARP in paraffin embedded human brain tissue using a TIPARP polyclonal antibody (Product # PA5-98589) at a dilution of 1:300. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is dete... View More
Product Details
PA5-98589
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human TCDD-inducible poly [ADP-ribose] polymerase protein (74-178AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TIPARP is a poly [ADP-ribose] polymerase using NAD+ as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. TIPARP may play a role in the adaptative response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP-ribosyltransferase diphtheria toxin-like 14; ARTD14; DDF1; DKFZP434J214; DKFZp686N0351; DKFZp686P1838; FLJ40466; PARP-1; PARP-7; Poly [ADP-ribose] polymerase 7; Protein mono-ADP-ribosyltransferase TIPARP; TCDD-inducible poly [ADP-ribose] polymerase; unnamed protein product
Gene Aliases: ARTD14; PARP7; pART14; TIPARP
UniProt ID: (Human) Q7Z3E1
Entrez Gene ID: (Human) 25976
core promoter proximal region sequence-specific DNA binding
NAD+ ADP-ribosyltransferase activity
zinc ion binding
transferase activity
transferase activity, transferring glycosyl groups
nucleotidyltransferase activity
metal ion binding
NAD+-protein-cysteine ADP-ribosyltransferase activity
NAD+-protein-aspartate ADP-ribosyltransferase activity
NAD+-protein-glutamate ADP-ribosyltransferase activity
protein ADP-ribosylase activity
vasculogenesis
kidney development
androgen metabolic process
estrogen metabolic process
female gonad development
post-embryonic development
negative regulation of gene expression
hemopoiesis
positive regulation of protein catabolic process
platelet-derived growth factor receptor signaling pathway
skeletal system morphogenesis
smooth muscle tissue development
palate development
face morphogenesis
response to 2,3,7,8-tetrachlorodibenzodioxine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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