|Western Blot (WB)||0.1-0.3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (QTLLKKPKKRPNSPE) corresponding to the internal amino acids of TIRAP|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The innate immune system recognizes microbial pathogens through Toll-like receptors domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; Mal; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-interleukin 1 receptor (TIR) domain-containing adapter protein; Toll-interleukin 1 receptor domain-containing adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein; wyatt
Gene Aliases: BACTS1; MAL; MyD88-2; TIRAP; wyatt
UniProt ID: (Human) P58753
Entrez Gene ID: (Human) 114609
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