Invitrogen

TIRAP Polyclonal Antibody

3 Published Figures
4 References
View all (17) TIRAP antibodies

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Product Details

PA5-88657

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:200
View 2 publications 2 publications

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.23 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2805059

Product Specific Information

Positive Samples: HeLa, Mouse lung, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Membrane

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein

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Gene Aliases: AA407980; BACTS1; C130027E04Rik; MAL; MyD88-2; TIRAP; Tlr4ap; Wyatt

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UniProt ID: (Human) P58753, (Mouse) Q99JY1

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Entrez Gene ID: (Human) 114609, (Mouse) 117149, (Rat) 680127

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Function(s)
protein kinase C binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein binding, bridging Toll-like receptor 4 binding Toll-like receptor 2 binding protein homodimerization activity protein heterodimerization activity molecular_function
Process(es)
immune system process inflammatory response signal transduction cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity response to bacterium myeloid cell differentiation positive regulation of B cell proliferation response to lipopolysaccharide regulation of interferon-beta production regulation of interleukin-15 production positive regulation of interleukin-12 production positive regulation of interleukin-15 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production positive regulation of toll-like receptor 2 signaling pathway positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway TIRAP-dependent toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of growth of symbiont in host innate immune response regulation of innate immune response positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of JNK cascade defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway 3'-UTR-mediated mRNA stabilization cellular response to bacterial lipopeptide cellular response to lipoteichoic acid positive regulation of neutrophil chemotaxis positive regulation of protein homodimerization activity positive regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 2 production MyD88-dependent toll-like receptor signaling pathway activation of NF-kappaB-inducing kinase activity toll-like receptor 4 signaling pathway biological_process
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