Immunogen sequence: MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP TSQDSPLPPS LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA QDLVSYLEGS TASLRCFLQL RDATPGGAIV SELCQALSSS HCRVLLITPG FLQDPWCKYQ MLQALTEAPG AEGCTIPLLS GLSRAAYPPE LRFMYYVDGR GPDGGFRQVK EAVMRYLQTL S; Positive Samples: HeLa, Mouse lung, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Membrane
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
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Protein Aliases: adapter protein wyatt; Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2; TIR domain-containing adapter protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; Toll-like receptor 4 adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein
Gene Aliases: AA407980; BACTS1; C130027E04Rik; MAL; MyD88-2; TIRAP; Tlr4ap; Wyatt