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Fabgennix
TIRAP3b Polyclonal Antibody
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Product Details
TIRAP-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Cat,
Human,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adaptor molecule
Gene Aliases: MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM
UniProt ID: (Human) Q86XR7
Entrez Gene ID: (Pig) 100520421, (Human) 353376
MyD88-independent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
negative regulation of MyD88-independent toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
necroptotic process
response to interleukin-12
cellular response to lipopolysaccharide
positive regulation of chemokine (C-C motif) ligand 5 production
apoptotic signaling pathway
positive regulation of interleukin-18-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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