Search
Invitrogen
TIS11D Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-101115
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ZFP36L2(Accession P47974), corresponding to amino acid residues T238-P288.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TISD.
Target Information
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Butyrate response factor 2; butyrate response factor 2 (EGF-response factor 2); EGF-response factor 2; ERF-2; mRNA decay activator protein ZFP36L2; Protein TIS11D; TISD; TPA-induced sequence 11d; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; Zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2
Gene Aliases: BRF2; ERF-2; ERF2; OOMD13; OZEMA13; RNF162C; TIS11D; ZFP36L2
UniProt ID: (Human) P47974, (Mouse) P23949
Entrez Gene ID: (Human) 678, (Mouse) 12193
MAPK cascade
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
mRNA catabolic process
response to wounding
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
regulation of B cell differentiation
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of mitotic cell cycle phase transition
negative regulation of stem cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support