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Invitrogen
TIS11D Polyclonal Antibody
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Product Details
PA5-40708
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human ZFP36L2 (aa 36-85).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: VGTPVAAAPS SGFAPGFLRR HSASNLHALA HPAPSPGSCS PKFPGAANGS
Sequence homology: Cow: 92%; Guinea Pig: 85%; Mouse: 84%; Rat: 84%
Target Information
TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Butyrate response factor 2; EGF-response factor 2; ERF-2; mRNA decay activator protein ZFP36L2; Protein TIS11D; TISD; TPA-induced sequence 11d; ZFP36 ring finger protein-like 2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; Zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2
Gene Aliases: BRF2; ERF-2; ERF2; RNF162C; TIS11D; ZFP36L2
UniProt ID: (Human) P47974
Entrez Gene ID: (Human) 678
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of transcription, DNA-templated
mRNA catabolic process
cell proliferation
response to wounding
hemopoiesis
T cell differentiation in thymus
somatic stem cell population maintenance
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
negative regulation of fat cell differentiation
somatic stem cell division
definitive hemopoiesis
3'-UTR-mediated mRNA destabilization
ERK1 and ERK2 cascade
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to transforming growth factor beta stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cellular response to phorbol 13-acetate 12-myristate
negative regulation of stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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