Proteintech

TK1 Polyclonal Antibody

TK1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

TK1 Antibody (15691-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using TK1 antibody 15691-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

TK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

TK1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15691-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TK1 Fusion Protein Ag8249 (1-234 aa encoded by BC007986)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSCINLPTV LPGSPSKTRG QIQVILGPMF SGKSTELMRR VRRFQIAQYK CLVIKYAKDT RYSSSFCTHD RNTMEALPAC LLRDVAQEAL GVAVIGIDEG QFFPDIVEFC EAMANAGKTV IVAALDGTFQ RKPFGAILNL VPLAESVVKL TAVCMECFRE AAYTKRLGTE KEVEVIGGAD KYHSVCRLCY FKKASGQPAG PDNKENCPVP GKPGEAVAAR KLFAPQQILQ CSPAN (1-234 aa encoded by BC007986)

Target Information

Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Cell metabolism

Li Q,Zhang L,Yang Q,Li M,Pan X,Xu J,Zhong C,Yao F,Zhang R,Zhou S,Dai X,Shi X,Dai Y,Xu J,Cheng X,Xiao W,She Z,Wang K,Qian X,Pu L,Zhang P,Wang X

Tue Jun 06 00:00:00 UTC 2023

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Cell metabolism

Li Q,Zhang L,Yang Q,Li M,Pan X,Xu J,Zhong C,Yao F,Zhang R,Zhou S,Dai X,Shi X,Dai Y,Xu J,Cheng X,Xiao W,She Z,Wang K,Qian X,Pu L,Zhang P,Wang X

Tue Jun 06 00:00:00 UTC 2023

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Cell metabolism

Li Q,Zhang L,Yang Q,Li M,Pan X,Xu J,Zhong C,Yao F,Zhang R,Zhou S,Dai X,Shi X,Dai Y,Xu J,Cheng X,Xiao W,She Z,Wang K,Qian X,Pu L,Zhang P,Wang X

Tue Jun 06 00:00:00 UTC 2023

Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners.

Cell metabolism

Li Q,Zhang L,Yang Q,Li M,Pan X,Xu J,Zhong C,Yao F,Zhang R,Zhou S,Dai X,Shi X,Dai Y,Xu J,Cheng X,Xiao W,She Z,Wang K,Qian X,Pu L,Zhang P,Wang X

Tue Jun 06 00:00:00 UTC 2023

Thymidine Kinase 1 Mediates the Synergistic Antitumor Activity of Ubenimex and Celecoxib via Regulation of Cell Cycle in Colorectal Cancer.

The Journal of pharmacology and experimental therapeutics

Wang A,Shang Y,Ni J,Wang W,Wang C,Li G,Chen SZ

Mon Aug 01 00:00:00 UTC 2022

lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.

Oxidative medicine and cellular longevity

Liang G,Zeng M,Gao M,Xing W,Jin X,Wang Q,Deng L,Ou H,He Z

Tue Mar 08 00:00:00 UTC 2022

Neutrophil extracellular traps accelerate vascular smooth muscle cell proliferation via Akt/CDKN1b/TK1 accompanying with the occurrence of hypertension.

Journal of hypertension

Fang X,Ma L,Wang Y,Ren F,Yu Y,Yuan Z,Wei H,Zhang H,Sun Y

Sat Oct 01 00:00:00 UTC 2022

Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury via interleukin-1 receptor antagonist.

Theranostics

Zhang L,Zhuang X,Kotitalo P,Keller T,Krzyczmonik A,Haaparanta-Solin M,Solin O,Forsback S,Grönroos TJ,Han C,López-Picón FR,Xia H

Thu Jul 22 00:00:00 UTC 2021

rAAV9-UPII-TK-EGFP can precisely transduce a suicide gene and inhibit the growth of bladder tumors.

Cancer biology & therapy

Lian F,Ye Q,Feng B,Cheng H,Niu S,Fan N,Wang D,Wang Z

Tue Dec 01 00:00:00 UTC 2020

Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.

Journal of cellular and molecular medicine

Jiang X,Wang J

Mon Jul 01 00:00:00 UTC 2019

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Advances in biological regulation

Schrock MS,Karras JR,Guggenbiller MJ,Druck T,Batar B,Huebner K

Sun Jan 01 00:00:00 UTC 2017

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Advances in biological regulation

Schrock MS,Karras JR,Guggenbiller MJ,Druck T,Batar B,Huebner K

Sun Jan 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: EC 2.7.1.21; KITH; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; Thymidine kinase, cytosolic; thymidine kinase-1

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Gene Aliases: D530002A18Rik; Tk; Tk-1; TK1; Tk1a; Tk1b; TK2

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UniProt ID: (Human) P04183, (Rat) P27158, (Mouse) P04184

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Entrez Gene ID: (Human) 7083, (Rat) 24834, (Mouse) 21877

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Function(s)

thymidine kinase activity protein binding ATP binding zinc ion binding nucleoside kinase activity identical protein binding molecular_function nucleotide binding kinase activity transferase activity metal ion binding nucleotide kinase

Process(es)

liver development nucleobase-containing compound metabolic process DNA metabolic process deoxyribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process response to toxic substance skeletal muscle cell proliferation phosphorylation response to nutrient levels pyrimidine nucleoside salvage thymidine metabolic process response to copper ion digestive tract development protein homotetramerization response to cortisol fetal process involved in parturition DNA biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TK1 Polyclonal Antibody

TK1 Antibody (15691-1-AP) in ICC/IF

Product Details

15691-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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