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Invitrogen
TK1 Polyclonal Antibody
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FIGURE: 1 / 7
TK1 Antibody (PA5-29686) in IHC (P)
TK1 Polyclonal Antibody detects Thymidine Kinase 1 protein at cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded rat ovary. Thymidine Kinase 1 stained by TK1 Polyclonal Antibody (Product # PA5-29686) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-29686
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Thymidine Kinase 1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.01 mg/mL
Amount
101 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, A431 cytoplasm extract.
Predicted reactivity: Mouse (91%), Rat (91%), Zebrafish (81%), Chicken (83%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytosolic thymidine kinase; EC 2.7.1.21; epididymis secretory sperm binding protein; KITH; thymidine kinase (EC 2.7.1.21); Thymidine kinase, cytosolic; unnamed protein product
Gene Aliases: D530002A18Rik; Tk; Tk-1; TK1; Tk1a; Tk1b; TK2
UniProt ID: (Human) P04183, (Rat) P27158, (Mouse) P04184
Entrez Gene ID: (Human) 7083, (Rat) 24834, (Mouse) 21877
nucleobase-containing compound metabolic process
deoxyribonucleoside monophosphate biosynthetic process
thymidine metabolic process
thymidine biosynthetic process
protein homotetramerization
DNA biosynthetic process
DNA synthesis involved in mitotic DNA replication
liver development
nucleotide biosynthetic process
response to toxic substance
skeletal muscle cell proliferation
phosphorylation
response to nutrient levels
response to copper ion
digestive tract development
response to cortisol
fetal process involved in parturition
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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