FIGURE: 1 / 5
Recommended positive controls: A431, A431 cytoplasm extract.
Predicted reactivity: Mouse (91%), Rat (91%), Zebrafish (81%), Chicken (83%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 22.214.171.124; KITH; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; Thymidine kinase, cytosolic; thymidine kinase-1
Gene Aliases: D530002A18Rik; Tk; Tk-1; TK1; Tk1a; Tk1b; TK2
Molecular Function: nucleotide kinase