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Invitrogen
TK2 Polyclonal Antibody
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Product Details
PA5-13813
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2
Conjugate
Form
Liquid
Concentration
1.6 mg/mL
Amount
640 µg
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2'-deoxyuridine kinase TK2; Deoxycytidine kinase TK2; mitochondrial thymidine kinase; Mt-TK; Thymidine kinase 2, mitochondrial; unnamed protein product
Gene Aliases: AU024611; mt-TK; MTDPS2; MTTK; PEOB3; SCA31; TK2; TK2-EXT
UniProt ID: (Human) O00142
Entrez Gene ID: (Human) 7084, (Mouse) 57813
nucleobase-containing compound metabolic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
pyrimidine nucleoside salvage
deoxycytidine metabolic process
thymidine metabolic process
DNA biosynthetic process
carbohydrate derivative metabolic process
mitochondrial DNA replication
deoxyribonucleotide metabolic process
phosphorylation
mitochondrial DNA metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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