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Invitrogen
TLE1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106930
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TLE1(Accession Q04724), corresponding to amino acid residues H307-G357.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TLE1.
Target Information
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1; Grg-1; Groucho-related protein 1; RP11-203D19.1; TLE 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like; Transducin-like enhancer protein 1; unnamed protein product
Gene Aliases: C230057C06Rik; ESG; ESG1; Estm14; Grg-1; GRG1; TLE-1; TLE1; Tle4l
UniProt ID: (Human) Q04724, (Mouse) Q62440
Entrez Gene ID: (Human) 7088, (Mouse) 21885, (Rat) 362533
regulation of transcription, DNA-templated
signal transduction
organ morphogenesis
positive regulation of gene expression
Wnt signaling pathway
negative regulation of Wnt signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
negative regulation of anoikis
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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