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Proteintech
TLR1 Polyclonal Antibody
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Product Details
19816-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TLR1 Fusion Protein Ag13852 (604-786 aa encoded by BC109093)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LDLPWYLRM VCQWTQTRRR ARNIPLEELQ RNLQFHAFIS YSGHDSFWVK NELLPNLEKE GMQICLHERN FVPGKSIVEN IITCIEKSYK SIFVLSPNFV QSEWCHYELY FAHHNLFHEG SNSLILILLE PIPQYSIPSS YHKLKSLMAR RTYLEWPKEK SKRGLFWANL RAAINIKLTE QAKK (604-786 aa encoded by B C109093)
Target Information
TLR1 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The Toll-like receptor (TLR) family in mammals are comprised of a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. The TLRs could constitute an important and unrecognized component of innate immunity in humans. In mice, TLR1 interacts with TLR2 and co-expression of TLR1 and TLR2 enhance the NF-kappaB activation in response to a synthetic lipopeptide. They recognize the lipid configuration of the native mycobacterial lipoprotein as well as several tri-acylated lipopeptides. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for the TLR1 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD281; TIL; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
Gene Aliases: CD281; KIAA0012; rsc786; TIL; TIL. LPRS5; TLR1
UniProt ID: (Human) Q15399, (Mouse) Q9EPQ1
Entrez Gene ID: (Human) 7096, (Mouse) 21897, (Rat) 305354
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
defense response
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
response to bacterial lipoprotein
toll-like receptor 1 signaling pathway
macrophage activation
detection of triacyl bacterial lipopeptide
positive regulation of tumor necrosis factor biosynthetic process
innate immune response
positive regulation of interleukin-6 biosynthetic process
regulation of cytokine secretion
cellular response to triacyl bacterial lipopeptide
toll-like receptor TLR1:TLR2 signaling pathway
defense response to bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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