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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Human Toll-like receptor (TLR2)|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Based on our testing, publications, and results reported from customers, the Alexa Fluor® 488 dye provides the best fluorescein (FITC) substitute.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
Analyte Specific Reagent
toll/interleukin-1 receptor-like protein 4, Toll-like Receptor 2, TIL4, toll/interleukin 1 receptor-like 4
Signal transduction Cell surface receptor mediated signal transduction Cytokine and chemokine mediated signaling pathway Immunity and defense T-cell mediated immunity Granulocyte-mediated immunity Macrophage-mediated immunity