Product References
Production of interleukin-1β related to mammalian target of rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the mouse cornea.
International journal of ophthalmology
Xu R,Lin J,Zhao GQ,Li C,Che CY,Xu Q,Liu M
Thu Oct 01 00:00:00 EDT 2020
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.
Frontiers in cellular neuroscience
Chen Y,Wang L,Zhang L,Chen B,Yang L,Li X,Li Y,Yu H
Thu Oct 01 00:00:00 EDT 2020
Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.
Frontiers in cellular neuroscience
Chen Y,Wang L,Zhang L,Chen B,Yang L,Li X,Li Y,Yu H
Thu Oct 01 00:00:00 EDT 2020
Boxb mediate BALB/c mice corneal inflammation through a TLR4/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis.
International journal of ophthalmology
Liu M,Li C,Zhao GQ,Lin J,Che CY,Xu Q,Wang Q,Xu R,Niu YW
Thu Oct 01 00:00:00 EDT 2020
Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-κB and NLRP3 inflammasome.
American journal of translational research
Du Y,Gu X,Meng H,Aa N,Liu S,Peng C,Ge Y,Yang Z
Wed Sep 30 00:00:00 EDT 2020
Neuroprotective Effect of β-Caryophyllene on Cerebral Ischemia-Reperfusion Injury via Regulation of Necroptotic Neuronal Death and Inflammation: In Vivo and in Vitro.
Frontiers in neuroscience
Yang M,Lv Y,Tian X,Lou J,An R,Zhang Q,Li M,Xu L,Dong Z
Wed Sep 30 00:00:00 EDT 2020
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.
Frontiers in aging neuroscience
Lai M,Yao H,Shah SZA,Wu W,Wang D,Zhao Y,Wang L,Zhou X,Zhao D,Yang L
Tue Sep 29 00:00:00 EDT 2020
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Frontiers in pharmacology
Zhang S,Wang Z,Zhu J,Xu T,Zhao Y,Zhao H,Tang F,Li Z,Zhou J,Gao D,Tian X,Yao J
Tue Sep 29 00:00:00 EDT 2020
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Frontiers in pharmacology
Liang S,Lv ZT,Zhang JM,Wang YT,Dong YH,Wang ZG,Chen K,Cheng P,Yang Q,Guo FJ,Lu WW,Zhu WT,Chen AM
Tue Sep 29 00:00:00 EDT 2020
Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice.
International journal of biological sciences
Li R,Li J,Huang Y,Li H,Yan S,Lin J,Chen Y,Wu L,Liu B,Wang G,Lan T
Mon Sep 09 00:00:00 EDT 2019
Polydatin attenuates diet-induced nonalcoholic steatohepatitis and fibrosis in mice.
International journal of biological sciences
Li R,Li J,Huang Y,Li H,Yan S,Lin J,Chen Y,Wu L,Liu B,Wang G,Lan T
Mon Sep 09 00:00:00 EDT 2019
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
Neuroscience bulletin
Sun J,Ren XS,Kang Y,Dai HB,Ding L,Tong N,Zhu GQ,Zhou YB
Fri Feb 01 00:00:00 EST 2019
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Brain, behavior, and immunity
Xu B,Zang SC,Li SZ,Guo JR,Wang JF,Wang D,Zhang LP,Yang HM,Lian S
Fri Feb 01 00:00:00 EST 2019
Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Song Q,Zhang Y,Han X,Zhang Y,Zhang X,Gao Y,Zhang J,Chu L,Zhao S
Tue Jan 01 00:00:00 EST 2019
Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats.
Toxicology
Wang P,Dai H,Zhang C,Tian J,Deng Y,Zhao M,Zhao M,Bing G,Zhao L
Sat Dec 01 00:00:00 EST 2018
Evaluation of the effects of chlorpyrifos combined with lipopolysaccharide stress on neuroinflammation and spatial memory in neonatal rats.
Toxicology
Wang P,Dai H,Zhang C,Tian J,Deng Y,Zhao M,Zhao M,Bing G,Zhao L
Sat Dec 01 00:00:00 EST 2018
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Neuroscience letters
Chen S,Lyu C,Zhou J,Huang S,Zhang Y,Liu G,Liu K,Chen D,Hu Y,Zhou L,Gu Y
Thu Nov 01 00:00:00 EDT 2018
Hypermucoviscous Klebsiella pneumoniae infections induce platelet aggregation and apoptosis and inhibit maturation of megakaryocytes.
Thrombosis research
Wang Z,Ren J,Liu Q,Li J,Wu X,Wang W,Wu J,Wang G,Li J
Thu Nov 01 00:00:00 EDT 2018
Toll-like receptor 4 shRNA attenuates lipopolysaccharide-induced epithelial-mesenchymal transition of intrahepatic biliary epithelial cells in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Tang S,Jiang X,Wu L,Chen S,Chen L,Jiang J,Yan P,Wang F,Tu K,Wang D,Gu J,Zhao L
Thu Nov 01 00:00:00 EDT 2018
Down-Regulation of miR-327 Alleviates Ischemia/Reperfusion-Induced Myocardial Damage by Targeting RP105.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Yang Y,Yang J,Liu XW,Ding JW,Li S,Guo X,Yang CJ,Fan ZX,Wang HB,Li Q,Wang HM,Yang J
Fri Oct 12 00:00:00 EDT 2018
Microcystin-leucine arginine (MC-LR) induced inflammatory response in bovine sertoli cell via TLR4/NF-kB signaling pathway.
Environmental toxicology and pharmacology
Adegoke EO,Wang C,Machebe NS,Wang X,Wang H,Adeniran SO,Zhang H,Zheng P,Zhang G
Mon Oct 01 00:00:00 EDT 2018
The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway.
Mediators of inflammation
Wang Y,Chen H,Chen Q,Jiao FZ,Zhang WB,Gong ZJ
Mon Sep 24 00:00:00 EDT 2018
The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway.
Mediators of inflammation
Wang Y,Chen H,Chen Q,Jiao FZ,Zhang WB,Gong ZJ
Mon Sep 24 00:00:00 EDT 2018
Moderate hypothermia inhibits microglial activation after traumatic brain injury by modulating autophagy/apoptosis and the MyD88-dependent TLR4 signaling pathway.
Journal of neuroinflammation
Zhang F,Dong H,Lv T,Jin K,Jin Y,Zhang X,Jiang J
Thu Sep 20 00:00:00 EDT 2018
Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus).
Medical science monitor : international medical journal of experimental and clinical research
Sun C,Chen Z,Wang H,Ding K
Tue Sep 18 00:00:00 EDT 2018
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Oxidative medicine and cellular longevity
Lin L,Li R,Cai M,Huang J,Huang W,Guo Y,Yang L,Yang G,Lan T,Zhu K
Mon Sep 17 00:00:00 EDT 2018
Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways.
Oxidative medicine and cellular longevity
Lin L,Li R,Cai M,Huang J,Huang W,Guo Y,Yang L,Yang G,Lan T,Zhu K
Mon Sep 17 00:00:00 EDT 2018
Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway.
Life sciences
Leng B,Tang F,Lu M,Zhang Z,Wang H,Zhang Y
Sat Sep 15 00:00:00 EDT 2018
Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population.
Journal of immunology research
Chen G,Xu M,Chen J,Hong L,Lin W,Zhao S,Zhang G,Dan G,Liu S
Fri Sep 07 00:00:00 EDT 2018
Liver injury induced in Balb/c mice by PM2.5 exposure and its alleviation by compound essential oils.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Ya P,Xu H,Ma Y,Fang M,Yan X,Zhou J,Li F
Sat Sep 01 00:00:00 EDT 2018
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Prostaglandins, leukotrienes, and essential fatty acids
Guo XF,Sinclair AJ,Kaur G,Li D
Sat Sep 01 00:00:00 EDT 2018
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
International journal of molecular medicine
Liu F,Wen Y,Kang J,Wei C,Wang M,Zheng Z,Peng J
Sat Sep 01 00:00:00 EDT 2018
Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.
Journal of ethnopharmacology
Liu H,Ma S,Xia H,Lou H,Zhu F,Sun L
Fri Aug 10 00:00:00 EDT 2018
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway.
International immunopharmacology
Ning C,Gao X,Wang C,Huo X,Liu Z,Sun H,Yang X,Sun P,Ma X,Meng Q,Liu K
Wed Aug 01 00:00:00 EDT 2018
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Behavioural brain research
Lian S,Wang D,Xu B,Guo W,Wang L,Li W,Ji H,Wang J,Kong F,Zhen L,Li S,Zhang L,Guo J,Yang H
Mon Jul 02 00:00:00 EDT 2018
Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway.
Molecular medicine reports
Xue S,He W,Zeng X,Tang Z,Feng S,Zhong Z,Xiong Y,Wang Y,Ye Q
Sun Jul 01 00:00:00 EDT 2018
Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice.
Translational research : the journal of laboratory and clinical medicine
Wang SH,Yu TY,Tsai FC,Weston CJ,Lin MS,Hung CS,Kao HL,Li YI,Solé M,Unzeta M,Chen YL,Chuang LM,Li HY
Sun Jul 01 00:00:00 EDT 2018
Gene transfer of a naked plasmid (pUDK-HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction-induced chronic post-surgical pain in rats.
European journal of pain (London, England)
Hu C,Lu Y,Chen X,Wu Z,Zhang Q
Tue May 01 00:00:00 EDT 2018
DFMG attenuates the activation of macrophages induced by co‑culture with LPC‑injured HUVE‑12 cells via the TLR4/MyD88/NF‑κB signaling pathway.
International journal of molecular medicine
Cong L,Yang S,Zhang Y,Cao J,Fu X
Tue May 01 00:00:00 EDT 2018
Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway.
Brain, behavior, and immunity
Sun MF,Zhu YL,Zhou ZL,Jia XB,Xu YD,Yang Q,Cui C,Shen YQ
Tue May 01 00:00:00 EDT 2018
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Molecular medicine reports
Liu X,Yin S,Chen Y,Wu Y,Zheng W,Dong H,Bai Y,Qin Y,Li J,Feng S,Zhao P
Sun Apr 01 00:00:00 EDT 2018
Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer's disease rats.
The Journal of nutritional biochemistry
Liu CB,Wang R,Yi YF,Gao Z,Chen YZ
Thu Mar 01 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Clinics and research in hepatology and gastroenterology
Zhang M,Hu X,Li S,Lu C,Li J,Zong Y,Qi W,Yang H
Thu Feb 01 00:00:00 EST 2018
Iridoids with Genipin Stem Nucleus Inhibit Lipopolysaccharide-Induced Inflammation and Oxidative Stress by Blocking the NF-κB Pathway in Polycystic Ovary Syndrome.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Zuo T,Zhu M,Xu W,Wang Z,Song H
Mon Jan 22 00:00:00 EST 2018
Oxytocin inhibited stress induced visceral hypersensitivity, enteric glial cells activation, and release of proinflammatory cytokines in maternal separated rats.
European journal of pharmacology
Xu S,Qin B,Shi A,Zhao J,Guo X,Dong L
Fri Jan 05 00:00:00 EST 2018
Kafirin from Sorghum bicolor inhibition of inflammation in THP-1 human macrophages is associated with reduction of intracellular reactive oxygen species.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Sullivan AC,Pangloli P,Dia VP
Mon Jan 01 00:00:00 EST 2018
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Oncotarget
Lian S,Guo J,Wang L,Li W,Wang J,Ji H,Kong F,Xu B,Li S,Yang H
Fri Dec 29 00:00:00 EST 2017
Glucocorticoid-induced leucine zipper overexpression inhibits lipopolysaccharide-induced retinal inflammation in rats.
Experimental eye research
Gu R,Lei B,Shu Q,Li G,Xu G
Fri Dec 01 00:00:00 EST 2017
fat-1 mice prevent high-fat plus high-sugar diet-induced non-alcoholic fatty liver disease.
Food & function
Guo XF,Gao JL,Li JM,Li D
Wed Nov 15 00:00:00 EST 2017
Toll‑like receptor 4 is expressed and functional in late endothelial progenitor cells.
Molecular medicine reports
Yu M,Wang C,Zeng G,Zeng G,Zhou L,Chen T,Tan X,Wang Y
Sun Oct 01 00:00:00 EDT 2017
TLR4 Influences Hepatitis B Virus Related Hepatocellular Carcinoma by Regulating the Wnt/β-Catenin Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Yin Y,Li F,Li S,Cai J,Shi J,Jiang Y
Fri Aug 04 00:00:00 EDT 2017
Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.
Scientific reports
Li C,Yu Y,Li W,Liu B,Jiao X,Song X,Lv C,Qin S
Wed Jul 19 00:00:00 EDT 2017
Influence of the total saponin fraction from Dioscorea nipponica Makino on TLR2/4-IL1R receptor singnal pathway in rats of gouty arthritis.
Journal of ethnopharmacology
Zhou Q,Lin FF,Liu SM,Sui XF
Wed Jul 12 00:00:00 EDT 2017
oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca2+ /K+ channel flow.
Journal of cellular and molecular medicine
Su J,Zhou H,Liu X,Nilsson J,Fredrikson GN,Zhao M
Mon May 01 00:00:00 EDT 2017
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
International journal of molecular medicine
Wang H,Xu YS,Wang ML,Cheng C,Bian R,Yuan H,Wang Y,Guo T,Zhu LL,Zhou H
Sat Apr 01 00:00:00 EDT 2017
1, 25(OH)2D3-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation.
Biochemical and biophysical research communications
Ma D,Zhang RN,Wen Y,Yin WN,Bai D,Zheng GY,Li JS,Zheng B,Wen JK
Sun Jan 08 00:00:00 EST 2017
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
Biochimica et biophysica acta
He K,Hu Y,Ma H,Zou Z,Xiao Y,Yang Y,Feng M,Li X,Ye X
Thu Sep 01 00:00:00 EDT 2016
Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway.
Inflammation
Wang Y,Chen G,Yu X,Li Y,Zhang L,He Z,Zhang N,Yang X,Zhao Y,Li N,Qiu H
Mon Aug 01 00:00:00 EDT 2016
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Nutrients
Tao X,Sun X,Xu L,Yin L,Han X,Qi Y,Xu Y,Zhao Y,Wang C,Peng J
Fri Jul 08 00:00:00 EDT 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 EDT 2016
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Environmental toxicology and pharmacology
Zhang W,Yin L,Tao X,Xu L,Zheng L,Han X,Xu Y,Wang C,Peng J
Fri Jul 01 00:00:00 EDT 2016
The effects of D3R on TLR4 signaling involved in the regulation of METH-mediated mast cells activation.
International immunopharmacology
Xue L,Geng Y,Li M,Jin YF,Ren HX,Li X,Wu F,Wang B,Cheng WY,Chen T,Chen YJ
Fri Jul 01 00:00:00 EDT 2016
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
International immunopharmacology
Yao H,Hu C,Yin L,Tao X,Xu L,Qi Y,Han X,Xu Y,Zhao Y,Wang C,Peng J
Fri Jul 01 00:00:00 EDT 2016
Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
European journal of pharmacology
Wu J,Zhang H,Hu B,Yang L,Wang P,Wang F,Meng X
Sun Jun 05 00:00:00 EDT 2016
Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways.
Journal of neurochemistry
Slusarczyk J,Trojan E,Glombik K,Piotrowska A,Budziszewska B,Kubera M,Popiolek-Barczyk K,Lason W,Mika J,Basta-Kaim A
Tue Mar 01 00:00:00 EST 2016
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Nutrients
Dong D,Yin L,Qi Y,Xu L,Peng J
Mon Jun 15 00:00:00 EDT 2015
Longistatin in tick saliva blocks advanced glycation end-product receptor activation.
The Journal of clinical investigation
Hatta T,Miyoshi T,Matsubayashi M,Islam MK,Alim MA,Anas MA,Hasan MM,Matsumoto Y,Yamamoto Y,Yamamoto H,Fujisaki K,Tsuji N
Wed Oct 01 00:00:00 EDT 2014
Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis.
Medical oncology (Northwood, London, England)
Ren WH,Zhang LM,Liu HQ,Gao L,Chen C,Qiang C,Wang XL,Liu CY,Li SM,Huang C,Qi H,Zhi KQ
Fri Aug 01 00:00:00 EDT 2014
Toll-like receptor 4 signaling contributes to Paclitaxel-induced peripheral neuropathy.
The journal of pain
Li Y,Zhang H,Zhang H,Kosturakis AK,Jawad AB,Dougherty PM
Tue Jul 01 00:00:00 EDT 2014
Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Shi H,Dong L,Dang X,Liu Y,Jiang J,Wang Y,Lu X,Guo X
Sat Jun 01 00:00:00 EDT 2013
Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
Toxicology
Shi H,Dong L,Jiang J,Zhao J,Zhao G,Dang X,Lu X,Jia M
Mon Jan 07 00:00:00 EST 2013