This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
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Protein Aliases: ARMD10; homolog of Drosophila toll; hToll; lipopolysaccharide response; TLR-4; TOLL; Toll-like Receptor 4; toll4
Gene Aliases: ARMD10; CD284; Lps; Ly87; Ran/M1; Rasl2-8; TLR-4; TOLL