Invitrogen

TLR4 Polyclonal Antibody

FIGURE: 1 / 31

TLR4 Antibody (48-2300) in WB

Western blot analysis was performed on membrane enriched extracts (30 µg lysate) of RAW 264.7 (Lane 1) and Hep G2 (Lane 2). The blot was probed with Anti-TLR4 Rabbit Polyclonal Antibody (Product # 48-2300, 2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 95 kDa band corresponding to TLR4 was observed across the cell lines tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 4-12... View More

TLR4 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

TLR4 Antibody in Immunohistochemistry (IHC)

TLR4 Antibody in Western Blot, Immunohistochemistry (WB, IHC)

TLR4 Antibody in Western Blot, Immunoprecipitation (WB, IP)

Product Image Gallery

TLR4 Antibody — Altered expression of protein upon cell treatment demonstrates antibody specificity. Western blot of TLR4 using Anti-TLR4 Rabbit Polyclonal Antibody (Product# 48-2300) shows increased expression of TLR4 in in HepG2 upon LPS treatment. {TM}

Product Details

48-2300

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50-1:200

View 23 publications 23 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Flow Cytometry (Flow)

20 µg x 10^6 cells

View 2 publications 2 publications

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Gel Shift (GS)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal region of the mouse TLR4 protein (Accession# NP_067272, Q9QUK6), which is identical to rat and 94% homologous to human.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533842

Target Information

TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Bifidobacterium mitigates autoimmune hepatitis by regulating IL-33-induced Treg/Th17 imbalance via the TLR2/4 signaling pathway.

Histology and histopathology

Song J,Dai J,Chen X,Ding F,Ding Y,Ma L,Zhang L

48-2300 was used in Western Blot to reveal that LCBLECs exerted therapeutic effects on EAH mice by improving Treg/Th17 imbalance in an IL-33-dependent manner via the TLR2/4 signaling pathway and relieved the clinical symptoms of AIH patients, indicating Bifidobacterium supplementation with LCBLECs might be a potential adjuvant therapy for AIH treatment.

Wed May 01 00:00:00 UTC 2024

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.

Frontiers in immunology

Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Flow Cytometry

Thu May 18 00:00:00 UTC 2023

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.

Frontiers in immunology

Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Flow Cytometry

Thu May 18 00:00:00 UTC 2023

TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.

Frontiers in immunology

Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Flow Cytometry

Thu May 18 00:00:00 UTC 2023

Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts.

Cells

Lopes E,Machado-Oliveira G,Simões CG,Ferreira IS,Ramos C,Ramalho J,Soares MIL,Melo TMVDPE,Puertollano R,Marques ARA,Vieira OV

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Wed Dec 13 00:00:00 UTC 2023

Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.

Frontiers in nutrition

Pirozzi C,Coretti L,Opallo N,Bove M,Annunziata C,Comella F,Turco L,Lama A,Trabace L,Meli R,Lembo F,Mattace Raso G

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Wed Aug 23 00:00:00 UTC 2023

Palmitoylethanolamide counteracts high-fat diet-induced gut dysfunction by reprogramming microbiota composition and affecting tryptophan metabolism.

Frontiers in nutrition

Pirozzi C,Coretti L,Opallo N,Bove M,Annunziata C,Comella F,Turco L,Lama A,Trabace L,Meli R,Lembo F,Mattace Raso G

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Wed Aug 23 00:00:00 UTC 2023

Fatty Acid-Binding Protein 4 is Essential for the Inflammatory and Metabolic Response of Microglia to Lipopolysaccharide.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology

Kagawa Y,Low YL,Pyun J,Doglione U,Short JL,Pan Y,Nicolazzo JA

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Fri Sep 01 00:00:00 UTC 2023

Celastrol attenuates Guillain-Barré syndrome by inhibiting TLR4/NF-κB/STAT3 pathway-mediated Th1/Th17 cell differentiation.

General physiology and biophysics

Shao H,Fan W,Tang Y

48-2300 was used in Western Blot to suggest that celastrol may exert therapeutic effects on GBS by suppressing TLR4/NF-κB/STAT3 pathway-mediated Th1/Th17 cell differentiation.

Sun Jan 01 00:00:00 UTC 2023

Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells.

Oxidative medicine and cellular longevity

de Sousa JAC,Azul FVCS,de Araújo AB,Tomé RC,Silva FRM,de Vasconcelos SMM,Rios FJ,Leal LKAM

48-2300 was used in Western Blotting to demonstrate the potent anti-inflammatory properties of EPI in microglial cells.

Tue May 09 00:00:00 UTC 2023

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.

International journal of molecular sciences

Vargas-Pozada EE,Ramos-Tovar E,Rodriguez-Callejas JD,Cardoso-Lezama I,Galindo-Gómez S,Talamás-Lara D,Vásquez-Garzón VR,Arellanes-Robledo J,Tsutsumi V,Villa-Treviño S,Muriel P

48-2300 was used in Western Blotting to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH.

Thu Sep 01 00:00:00 UTC 2022

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model.

International journal of molecular sciences

Vargas-Pozada EE,Ramos-Tovar E,Rodriguez-Callejas JD,Cardoso-Lezama I,Galindo-Gómez S,Talamás-Lara D,Vásquez-Garzón VR,Arellanes-Robledo J,Tsutsumi V,Villa-Treviño S,Muriel P

48-2300 was used in Western Blotting to evaluate the effect of caffeine on the NLRP3 inflammasome signaling pathway in a rat model of NASH.

Thu Sep 01 00:00:00 UTC 2022

Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats.

Life (Basel, Switzerland)

Mohamed ME,Younis NS

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunohistochemistry

Tue Sep 27 00:00:00 UTC 2022

Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats.

Life (Basel, Switzerland)

Mohamed ME,Younis NS

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunohistochemistry

Tue Sep 27 00:00:00 UTC 2022

Ishige okamurae Attenuates Neuroinflammation and Cognitive Deficits in Mice Intracerebroventricularly Injected with LPS via Regulating TLR-4/MyD88-Dependent Pathways.

Antioxidants (Basel, Switzerland)

Kwon OY,Lee SH

48-2300 was used in Western Blotting to demonstrate anti-neuroinflammatory activity of Ishige okamuae (IOE) by regulation of TLR-4/MyD88-dependent signaling pathways.

Thu Dec 29 00:00:00 UTC 2022

Ishige okamurae Attenuates Neuroinflammation and Cognitive Deficits in Mice Intracerebroventricularly Injected with LPS via Regulating TLR-4/MyD88-Dependent Pathways.

Antioxidants (Basel, Switzerland)

Kwon OY,Lee SH

48-2300 was used in Western Blotting to demonstrate anti-neuroinflammatory activity of Ishige okamuae (IOE) by regulation of TLR-4/MyD88-dependent signaling pathways.

Thu Dec 29 00:00:00 UTC 2022

Exosomal RNF157 mRNA from prostate cancer cells contributes to M2 macrophage polarization through destabilizing HDAC1.

Frontiers in oncology

Guan H,Mao L,Wang J,Wang S,Yang S,Wu H,Sun W,Chen Z,Chen M

48-2300 was used in Western Blot to investigate the role of exosomal RNF157 mRNA in prostate cancer development.

Fri Oct 21 00:00:00 UTC 2022

Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile.

American journal of physiology. Regulatory, integrative and comparative physiology

Belanger KM,Mohamed R,Webb RC,Sullivan JC

48-2300 was used in Western Blotting to indicate that although male spontaneously hypertensive rats (SHR) have greater renal TLR4 expression than females, TLR4 does not contribute to the higher blood pressure and more proinflammatory renal T cell profile in males versus females.

Fri Apr 01 00:00:00 UTC 2022

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.

Science translational medicine

Yu J,Zhu C,Wang X,Kim K,Bartolome A,Dongiovanni P,Yates KP,Valenti L,Carrer M,Sadowski T,Qiang L,Tabas I,Lavine JE,Pajvani UB

48-2300 was used in Immunohistochemistry to identify if increased expression of the Notch ligand Jagged1 (JAG1) tracked with Notch activation and nonalcoholic fatty liver disease (NAFLD) activity score (NAS) in human liver biopsy specimens and mouse NASH models.

Wed Jun 23 00:00:00 UTC 2021

Fetuin-A secretion from β-cells leads to accumulation of macrophages in islets, aggravates inflammation and impairs insulin secretion.

Journal of cell science

Mukhuty A,Fouzder C,Kundu R

48-2300 was used in Flow cytometry/Cell sorting to support an association of fetuin-A with islet inflammation and β-cell dysfunction, owing to its role as a key chemoattractant and macrophage polarizing factor.

Mon Nov 01 00:00:00 UTC 2021

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats.

Clinical and experimental pharmacology & physiology

Badawi GA,Shokr MM,Zaki HF,Mohamed AF

48-2300 was used in Western Blotting to find that PTX or its combination with phenytoin represent a promising drug to inhibit the epilepsy progression via targeting the HMGB1/TLR4/RAGE signalling pathway.

Sun Aug 01 00:00:00 UTC 2021

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats.

Clinical and experimental pharmacology & physiology

Badawi GA,Shokr MM,Zaki HF,Mohamed AF

Sun Aug 01 00:00:00 UTC 2021

Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways.

Evidence-based complementary and alternative medicine : eCAM

Liu L,Zhou Y,Dai D,Xia H,Zhao K,Zhang J

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Tue Aug 24 00:00:00 UTC 2021

Antifibrotic Effects of Kangxian Ruangan Capsule on Rats with Nonalcoholic Fatty Liver Fibrosis and Hepatic Stellate Cells through Regulation of TGF-β and TLR4 Signaling Pathways.

Evidence-based complementary and alternative medicine : eCAM

Liu L,Zhou Y,Dai D,Xia H,Zhao K,Zhang J

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Tue Aug 24 00:00:00 UTC 2021

hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis.

Scientific reports

Lagosz-Cwik KB,Wielento A,Lipska W,Kantorowicz M,Darczuk D,Kaczmarzyk T,Gibbs S,Potempa J,Grabiec AM

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Mon May 24 00:00:00 UTC 2021

hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis.

Scientific reports

Lagosz-Cwik KB,Wielento A,Lipska W,Kantorowicz M,Darczuk D,Kaczmarzyk T,Gibbs S,Potempa J,Grabiec AM

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Mon May 24 00:00:00 UTC 2021

The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties.

Journal of neuroinflammation

Buzhdygan TP,Rodrigues CR,McGary HM,Khan JA,Andrews AM,Rawls SM,Ramirez SH

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Mon Mar 01 00:00:00 UTC 2021

The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties.

Journal of neuroinflammation

Buzhdygan TP,Rodrigues CR,McGary HM,Khan JA,Andrews AM,Rawls SM,Ramirez SH

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Mon Mar 01 00:00:00 UTC 2021

Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.

Journal of neuroinflammation

Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Fri Mar 05 00:00:00 UTC 2021

Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.

Journal of neuroinflammation

Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Fri Mar 05 00:00:00 UTC 2021

Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.

Journal of neuroinflammation

Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Fri Mar 05 00:00:00 UTC 2021

Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis.

Journal of neuroinflammation

Su W,Cui H,Wu D,Yu J,Ma L,Zhang X,Huang Y,Ma C

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Fri Mar 05 00:00:00 UTC 2021

Distinct effects of calcineurin dependent and independent immunosuppressants on endotoxaemia-induced nephrotoxicity in rats: Role of androgens.

Clinical and experimental pharmacology & physiology

Elzokm SS,Fouda MA,Abdel Moneim RA,El-Mas MM

48-2300 was used in Western Blotting to reveal opposite effects for calcineurin-dependent (exaggeration) and -independent immunosuppressants (amelioration) on renal defects of endotoxaemia and implicate androgenic pathways in the worsened endotoxic renal profile induced by CNIs.

Wed Sep 01 00:00:00 UTC 2021

Solute carrier family 12 member 8 impacts the biological behaviors of breast carcinoma cells by activating TLR/NLR signaling pathway.

Cytotechnology

Li L,Xia J,Cui R,Kong B

48-2300 was used in Western Blotting to suggest that SLC12A8 plays a promoting effect on the cells viability, invasiveness and motility in breast carcinoma by activating TLR/NLR signaling pathway.

Mon Feb 01 00:00:00 UTC 2021

Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.

The Journal of experimental medicine

Lim TJF,Bunjamin M,Ruedl C,Su IH

48-2300 was used in Western Blotting to investigate the role and mechanism of Talin in regulating skin dendritic cells (DCs) during inflammatory responses.

Mon Aug 03 00:00:00 UTC 2020

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.

eLife

Hussain S,Johnson CG,Sciurba J,Meng X,Stober VP,Liu C,Cyphert-Daly JM,Bulek K,Qian W,Solis A,Sakamachi Y,Trempus CS,Aloor JJ,Gowdy KM,Foster WM,Hollingsworth JW,Tighe RM,Li X,Fessler MB,Garantziotis S

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunoprecipitation

Tue Jan 28 00:00:00 UTC 2020

TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.

eLife

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Immunoprecipitation

Tue Jan 28 00:00:00 UTC 2020

Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway.

Molecular medicine reports

Zhang L,Chen Q,Wang H,Yang J,Sheng S

Published figure using TLR4 polyclonal antibody (Product # 48-2300) in Western Blot

Sat Dec 01 00:00:00 UTC 2018

Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages.

PloS one

Bueno-Silva B,Kawamoto D,Ando-Suguimoto ES,Alencar SM,Rosalen PL,Mayer MP

48-2300 was used in Western Blotting to evaluate whether Brazilian red propolis attenuates the inflammatory effect of lipopolysaccharide on macrophages, and investigate the underlying mechanisms.

Wed Jul 06 00:00:00 UTC 2016

Vizantin inhibits endotoxin-mediated immune responses via the TLR 4/MD-2 complex.

Journal of immunology (Baltimore, Md. : 1950)

Oda M,Yamamoto H,Shibutani M,Nakano M,Yabiku K,Tarui T,Kameyama N,Shirakawa D,Obayashi S,Watanabe N,Nakase H,Suenaga M,Matsunaga Y,Nagahama M,Takahashi H,Imagawa H,Kurosawa M,Terao Y,Nishizawa M,Sakurai J

48-2300 was used in immunocytochemistry and western blot to investigate the effect of vizantin on endotoxin-mediated immune responses

Sat Nov 01 00:00:00 UTC 2014

TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.

PloS one

Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H

48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy

Fri Jan 09 00:00:00 UTC 2015

TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.

PloS one

Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H

48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy

Fri Jan 09 00:00:00 UTC 2015

TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy.

PloS one

Ma J,Chadban SJ,Zhao CY,Chen X,Kwan T,Panchapakesan U,Pollock CA,Wu H

48-2300 was used in immunohistochemistry - paraffin section to examine the contribution of TLR4 to diabetic nephropathy

Fri Jan 09 00:00:00 UTC 2015

Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens.

Placenta

Arce RM,Barros SP,Wacker B,Peters B,Moss K,Offenbacher S

Sun Feb 01 00:00:00 UTC 2009

Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori.

International journal of medical microbiology : IJMM

Schmausser B,Andrulis M,Endrich S,Müller-Hermelink HK,Eck M

Wed Jun 01 00:00:00 UTC 2005

Bioinformatics

Protein Aliases: CD284; homolog of Drosophila toll; hToll; lipopolysaccharide response; Toll-like receptor 4; Toll4

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Gene Aliases: ARMD10; CD284; Lps; Ly87; Ran/M1; Rasl2-8; TLR-4; TLR4; TOLL

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UniProt ID: (Human) D1CS53, (Mouse) Q9QUK6, (Rat) Q9QX05

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Entrez Gene ID: (Human) 7099, (Mouse) 21898, (Rat) 29260

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Function(s)

lipopolysaccharide binding lipopolysaccharide receptor activity receptor activity transmembrane signaling receptor activity protein binding phosphatidylinositol 3-kinase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TLR4 Polyclonal Antibody

TLR4 Antibody (48-2300) in WB

Product Details

48-2300

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Gel Shift (GS)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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