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Invitrogen
TLR6 Polyclonal Antibody
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Product Details
PA5-20187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 15 amino acids near the amino terminus of human TLR6.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is Jurkat cell lysate.
PA5-20187 can be used with blocking peptide PEP-0317.
Target Information
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 286; CD286; Toll-like receptor 6
Gene Aliases: CD286; TLR6
UniProt ID: (Human) Q9Y2C9, (Mouse) Q9EPW9
Entrez Gene ID: (Human) 10333, (Mouse) 21899
microglial cell activation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
response to bacterial lipoprotein
toll-like receptor 6 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interleukin-12 biosynthetic process
innate immune response
positive regulation of interleukin-6 biosynthetic process
nitric oxide metabolic process
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
activation of NF-kappaB-inducing kinase activity
toll-like receptor TLR6:TLR2 signaling pathway
defense response to bacterium
interleukin-1 beta secretion
positive regulation of NLRP3 inflammasome complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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