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Huabio
TLR7 Polyclonal Antibody
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Product Details
ER30606
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within mouse TLR7 aa 597-640
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RP23-139P21.3; Toll-like receptor 7; toll-like receptor 7-like; unnamed protein product
Gene Aliases: IMD74; RGD1563357; SLEB17; TLR7; TLR7-like; UNQ248/PRO285
UniProt ID: (Human) Q9NYK1, (Mouse) P58681
Entrez Gene ID: (Human) 51284, (Mouse) 170743, (Rat) 317468
MAPK cascade
toll-like receptor signaling pathway
immune system process
inflammatory response
immune response
signal transduction
I-kappaB kinase/NF-kappaB signaling
JNK cascade
positive regulation of chemokine production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
toll-like receptor 7 signaling pathway
toll-like receptor 8 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
defense response to virus
positive regulation of macrophage cytokine production
response to cGMP
cellular response to mechanical stimulus
defense response to other organism
cellular response to virus
endolysosomal toll-like receptor signaling pathway
microglial cell activation
regulation of protein phosphorylation
MyD88-dependent toll-like receptor signaling pathway
I-kappaB phosphorylation
positive regulation of NF-kappaB import into nucleus
positive regulation of interferon-gamma biosynthetic process
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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