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TLR7 Polyclonal Antibody, FITC

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TLR7 Polyclonal Antibody, FITC

Product Details

TLR7-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Cat, Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 175-225 on human TLR7 protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. TLR7 recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: RP23-139P21.3; Toll-like receptor 7; toll-like receptor 7-like; unnamed protein product

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Gene Aliases: IMD74; SLEB17; TLR7; TLR7-like; UNQ248/PRO285

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UniProt ID: (Human) Q9NYK1, (Mouse) P58681

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Entrez Gene ID: (Human) 51284, (Pig) 100037296, (Cat) 493685, (Mouse) 170743

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Function(s)
double-stranded RNA binding single-stranded RNA binding protein binding siRNA binding pattern recognition receptor activity transmembrane signaling receptor activity drug binding
Process(es)
MAPK cascade toll-like receptor signaling pathway immune system process inflammatory response immune response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-6 production positive regulation of interleukin-8 production toll-like receptor 7 signaling pathway toll-like receptor 8 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response defense response to virus positive regulation of macrophage cytokine production response to cGMP cellular response to mechanical stimulus defense response to other organism cellular response to virus endolysosomal toll-like receptor signaling pathway microglial cell activation regulation of protein phosphorylation MyD88-dependent toll-like receptor signaling pathway I-kappaB phosphorylation positive regulation of NF-kappaB import into nucleus positive regulation of interferon-gamma biosynthetic process positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of interleukin-8 biosynthetic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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