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Invitrogen
TLR8 Polyclonal Antibody
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FIGURE: 1 / 6
TLR8 Antibody (PA5-90109) in IHC (P)
Immunohistochemistry analysis of TLR8 in paraffin-embedded human liver cancer. Samples were incubated with TLR8 Polyclonal antibody (Product # PA5-90109) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-90109
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 849-1041 of human TLR8 (NP_6195421)
Conjugate
Form
Liquid
Concentration
2.16 mg/mL
Amount
216 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: HHLFYWDVWF IYNVCLAKVK GYRSLSTSQT FYDAYISYDT KDASVTDWVI NELRYHLEES RDKNVLLCLE ERDWDPGLAI IDNLMQSINQ SKKTVFVLTK KYAKSWNFKT AFYLALQRLM DENMDVIIFI LLEPVLQHSQ YLRLRQRICK SSILQWPDNP KAEGLFWQTL RNVVLTENDS RYNNMYVDSI KQY
Target Information
The TLR8 protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. The TLR8 gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen 288; CD288; TLR8; TLR8 isoform 1; Toll-like receptor 8; unnamed protein product
Gene Aliases: CD288; hTLR8; IMD98; TLR-8; TLR8; UNQ249/PRO286
UniProt ID: (Human) Q9NR97, (Mouse) P58682
Entrez Gene ID: (Human) 51311, (Mouse) 170744, (Rat) 684440
microglial cell activation
regulation of protein phosphorylation
toll-like receptor signaling pathway
immune system process
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
response to virus
toll-like receptor 8 signaling pathway
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interleukin-8 biosynthetic process
regulation of cytokine secretion
defense response to virus
immune response
immunoglobulin mediated immune response
negative regulation of interleukin-12 production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to mechanical stimulus
defense response to other organism
endolysosomal toll-like receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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