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TLR9 Polyclonal Antibody
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FIGURE: 1 / 2
TLR9 Antibody (OST00297W-100UL) in ICC/IF
IF on human plasmacytoid dendritic cells. Cells were fixed with 2% formaldehyde for 10 minutes at 37°C. Washed twice with PBS before cytospin the cells onto microscope slides. Cells were blocked with PBS containing 1%BSA for 20 minutes at room temperature (RT). Excess of blocking solution was removed and cells were then incubated with Rabbit antibody to TLR9 (830-880) ( OST00297W) for 30 min at RT (diluted 1:100 in the blocking buffer). Washed 3X with PBS and incubated with anti-Rabbit Alexa 586 for further 30 minutes. Washed as before and... View More
Product Details
OST00297W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 830-880 of human TLR9 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TLR9.
Target Information
The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform
Gene Aliases: CD289; TLR9; UNQ5798/PRO19605
UniProt ID: (Human) Q9NR96
Entrez Gene ID: (Human) 54106
microglial cell activation
positive regulation of cytokine production
activation of innate immune response
toll-like receptor signaling pathway
immune system process
positive regulation of immunoglobulin production
regulation of dendritic cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
I-kappaB kinase/NF-kappaB signaling
male gonad development
response to virus
positive regulation of autophagy
positive regulation of gene expression
maintenance of gastrointestinal epithelium
positive regulation of B cell proliferation
positive regulation of type I interferon production
detection of molecule of bacterial origin
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
toll-like receptor 9 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
regulation of B cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
regulation of inflammatory response
positive regulation of inflammatory response
defense response to Gram-negative bacterium
regulation of B cell activation
positive regulation of B cell activation
defense response to virus
negative regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to metal ion
defense response to other organism
endolysosomal toll-like receptor signaling pathway
negative regulation of calcium-transporting ATPase activity
cellular response to chloroquine
positive regulation of intestinal epithelial cell development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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