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Invitrogen

TLR9 Polyclonal Antibody, Alexa Fluor™ 488

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TLR9 Polyclonal Antibody, Alexa Fluor™ 488

Product Details

PA5-46898

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µL per million cells
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived recombinant human TLR9 Asn64-Glu189
3D Epitope / Immunogen

Conjugate

Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488

Excitation/Emission Max

499/520 nm View spectra spectra

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

Buffered saline solution with BSA

Contains

0.09% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2577052

Product Specific Information

In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse TLR9 is observed, and less than 1% cross-reactivity with recombinant human (rh) TLR1, rhTLR2, rhTLR3, rhTLR4, rhTLR5, rhTLR7, rhTLR8, and rhTLR10 is observed.

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Bioinformatics

Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform

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Gene Aliases: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96

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Entrez Gene ID: (Human) 54106

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Function(s)
interleukin-1 receptor binding siRNA binding pattern recognition receptor activity protein homodimerization activity unmethylated CpG binding
Process(es)
microglial cell activation positive regulation of cytokine production activation of innate immune response toll-like receptor signaling pathway immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway inflammatory response immune response signal transduction I-kappaB kinase/NF-kappaB signaling male gonad development response to virus positive regulation of autophagy positive regulation of gene expression maintenance of gastrointestinal epithelium positive regulation of B cell proliferation positive regulation of type I interferon production detection of molecule of bacterial origin positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response regulation of B cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation defense response to virus negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to metal ion defense response to other organism endolysosomal toll-like receptor signaling pathway negative regulation of calcium-transporting ATPase activity cellular response to chloroquine positive regulation of intestinal epithelial cell development
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