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Fabgennix

TLR9 Polyclonal Antibody

View all (41) TLR9 antibodies

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TLR9 Polyclonal Antibody

Product Details

TLR-901AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Chimpanzee, Human, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 430-460 on human TLR9 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform

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Gene Aliases: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96

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Entrez Gene ID: (Human) 54106, (Chimpanzee) 470827, (Rat) 338457

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Function(s)
interleukin-1 receptor binding siRNA binding pattern recognition receptor activity protein homodimerization activity unmethylated CpG binding transmembrane signaling receptor activity
Process(es)
microglial cell activation regulation of protein phosphorylation toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway immune response I-kappaB phosphorylation male gonad development response to virus positive regulation of autophagy maintenance of gastrointestinal epithelium negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway positive regulation of toll-like receptor signaling pathway toll-like receptor 9 signaling pathway positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JUN kinase activity positive regulation of interferon-gamma biosynthetic process innate immune response positive regulation of interferon-alpha biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of transcription from RNA polymerase II promoter regulation of cytokine secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of NF-kappaB transcription factor activity defense response to virus positive regulation of nitric-oxide synthase biosynthetic process cellular response to lipopolysaccharide cellular response to metal ion positive regulation of cytokine production activation of innate immune response immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling positive regulation of gene expression positive regulation of B cell proliferation positive regulation of type I interferon production detection of molecule of bacterial origin positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of toll-like receptor 9 signaling pathway defense response to bacterium positive regulation of MAPK cascade regulation of B cell differentiation positive regulation of JNK cascade positive regulation of B cell activation negative regulation of ERK1 and ERK2 cascade defense response to other organism endolysosomal toll-like receptor signaling pathway negative regulation of calcium-transporting ATPase activity cellular response to chloroquine positive regulation of intestinal epithelial cell development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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