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Invitrogen
TLX Polyclonal Antibody
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Product Details
PA5-40484
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human NR2E1 (aa 1-50).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: MSKPAGSTSR ILDIPCKVCG DRSSGKHYGV YACDGCSGFF KRSIRRNRTY
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HTll; NR2E1; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; similar to Drosophila tailless; tailes-related receptor; tailless; Tll; TLX; unnamed protein product
Gene Aliases: NR2E1; TLL; TLX; XTLL
UniProt ID: (Human) Q9Y466
Entrez Gene ID: (Human) 7101
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
enzyme binding
histone deacetylase binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
behavioral fear response
positive regulation of neuroblast proliferation
aggressive behavior
regulation of transcription, DNA-templated
apoptotic process
nervous system development
neuroblast proliferation
brain development
visual perception
cell proliferation
positive regulation of cell proliferation
dentate gyrus development
amygdala development
olfactory bulb development
layer formation in cerebral cortex
forebrain generation of neurons
cerebral cortex neuron differentiation
central nervous system neuron differentiation
anterior commissure morphogenesis
cerebral cortex development
cell differentiation
extracellular matrix organization
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
somatic stem cell population maintenance
social behavior
camera-type eye development
negative regulation of apoptotic process
astrocyte cell migration
cell fate commitment
negative regulation of neuron differentiation
positive regulation of angiogenesis
positive regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
astrocyte differentiation
negative regulation of astrocyte differentiation
regulation of dendrite morphogenesis
regulation of cellular component organization
retina development in camera-type eye
regulation of timing of neuron differentiation
long-term synaptic potentiation
neural precursor cell proliferation
regulation of cell migration involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
positive regulation of neural precursor cell proliferation
positive regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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