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Proteintech
TMBIM6 Polyclonal Antibody
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Product Details
26782-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMBIM6 Fusion Protein Ag24780
Conjugate
Form
Liquid
Concentration
467 µg/mL
Amount
70.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bax inhibitor 1; BI-1; TEGT; testis enhanced gene transcript; Testis-enhanced gene transcript protein; testis-enhanced gene transcript protein; integral membrane protein; Transmembrane BAX inhibitor motif-containing protein 6; unnamed protein product
Gene Aliases: 5031406P05Rik; BAXI1; BI-1; BI1; TEGT; TMBIM6
UniProt ID: (Human) P55061, (Mouse) Q9D2C7
Entrez Gene ID: (Human) 7009, (Mouse) 110213
negative regulation of transcription from RNA polymerase II promoter
negative regulation of immunoglobulin production
autophagy
apoptotic process
response to unfolded protein
negative regulation of calcium ion transport into cytosol
endoplasmic reticulum calcium ion homeostasis
negative regulation of RNA splicing
cellular response to unfolded protein
response to endoplasmic reticulum stress
neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response
negative regulation of apoptotic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
response to L-glutamate
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of IRE1-mediated unfolded protein response
negative regulation of apoptotic signaling pathway
negative regulation of mRNA cleavage
negative regulation of protein binding
negative regulation of immunoglobulin secretion
negative regulation of endoribonuclease activity
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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