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Invitrogen
TMC6 Polyclonal Antibody
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Product Details
PA5-20504
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the amino terminus of human EVER1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is A-20 cell lysate.
PA5-20504 can be used with blocking peptide PEP-0624.
Target Information
TMC6 interacts with, and forms a complex with the zinc transporter 1, SLC30A1, and localizes to the endoplasmic reticulum, nuclear membrane and Golgi apparatus. The inactivation of the TMC6 gene has been implicated in the skin disorder epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. TMC6 encodes integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. Diseases associated with TMC6 include Epidermodysplasia Verruciformis and Superficial Mycosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epidermodysplasia verruciformis 1; Epidermodysplasia verruciformis protein 1; expressed in activated T/LAK lymphocytes; LAK-4P; LEVER1; Protein LAK-4; SEVER1; TMC6; TNRC6C antisense RNA 1; Transmembrane channel-like protein 6; unnamed protein product
Gene Aliases: D11Ertd204e; EV1; EVER1; EVIN1; LAK-4P; lnc; TMC6; TNRC6C-AS1
UniProt ID: (Human) Q7Z403, (Mouse) Q7TN60
Entrez Gene ID: (Human) 11322, (Mouse) 217353
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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