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Product Details
PA5-104440
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TMC7(Accession Q7Z402), corresponding to amino acid residues C676-N723.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853745
Product Specific Information
Antibody detects endogenous levels of total TMC7.
Target Information
TMC7 (Transmembrane channel-like protein 7) is a 723 amino acid protein that is a member of the TMC protein family. All TMC genes encode transmembrane proteins with intracellular amino- and carboxy- termini and at least eight membrane spanning domains. Therefore, TMC7 is a multi-pass membrane protein that may regulate or function as an ion channel or transporter. The gene encoding TMC7 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: transmembrane channel-like 7; Transmembrane channel-like protein 7
Gene Aliases: 1700030H01Rik; C230064B05; C630024K23Rik; RGD1564267; TMC7
UniProt ID: (Human) Q7Z402, (Mouse) Q8C428
Entrez Gene ID: (Human) 79905, (Mouse) 209760, (Rat) 499254
Performance Guarantee
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