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Proteintech
TMEM106A Polyclonal Antibody
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Product Details
20460-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMEM106A Fusion Protein Ag14294 (143-262 aa encoded by BC012139)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TNILNISNG NYYPIMVTQL TLEVLHLSLV VGQVSNNLLL HIGPLASEQM FYAVATKIRD ENTYKICTWL EIKVHHVLLH IQGTLTCSYL SHSEQLVFQS YEYVDCRGNA SVPHQLTPHP P (143-262 aa encoded by BC012139)
Target Information
Transmembrane protein 106A (TMEM106A) is a single-pass transmembrane protein that is closely related to TMEM106B, a protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual roles of TMEM106A and TMEM106B are still undetermined; however, as TMEM106B is involved in FTLD, it is possible that TMEM106A may also be a risk factor for FTLD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Transmembrane protein 106A; unnamed protein product
Gene Aliases: TMEM106A
UniProt ID: (Human) Q96A25
Entrez Gene ID: (Human) 113277
immune system process
glycoprotein biosynthetic process
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
macrophage activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
positive regulation of MHC class II biosynthetic process
positive regulation of nitric oxide metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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