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Proteintech
TMEM119 Polyclonal Antibody
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Product Details
27585-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TMEM119 Fusion Protein Ag26269 (119-218 aa encoded by NM_181724)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
27585-1-AP recognizes a 45-50 kDa band likely due to glycosylation.
Immunogen sequence: MRQKQKASA YYPSSFPKKK YVDQSDRAGG PRAFSEVPDR APDSRPEEAL DSSRQLQADI LAATQNLKSP TRAALGGGDG ARMVEGRGAE EEEKGSQEGD QE (119-218 aa encoded by NM_181724)
Target Information
Tmem119 encodes a single-pass type I transmembrane protein which seems to interact with a multitude of micro-RNAs as well as certain transcription factors such as SMAD1, SMAD5 and RUNX2. Tmem119 has been identified as a surface marker of microglia that can be used to reliably distinguish microglia from infiltrating macrophages. Microglial cells are phagocytes that are restricted to the brain and involved in clearing up debris and dendrite pruning of neurons. They display a high functional plasticity, balancing neuroprotective and neurotoxic functions, which is reflected by their distinct physiology in response to changes in their microenvironment. Microglia are particularly mobile in areas of the brain undergoing restructuring. Reactive microglia co-express the marker Iba1. In a pathological context, microglia have been associated with differentiation of pathogenic/inflammatory A1 type astrocytes by secretion of Cq1, IL-1a and TNF when stimulated with LPS, and thought to contribute to the pathology of several neurodegenerative diseases such as Alzheimers, Parkinsons, Chorea Huntingtons disease and Multiple Sclerosis. The specific function Tmem119 plays on microglial cells remains unclear. Outside of the neural system, Tmem119 seems to be involved in osteoblast differentiation/ossification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: OBIF; Osteoblast induction factor; Transmembrane protein 119
Gene Aliases: AW208946; BC025600; OBIF; PSEC0199; TMEM119; UNQ731/PRO1415
UniProt ID: (Human) Q4V9L6, (Mouse) Q8R138
Entrez Gene ID: (Human) 338773, (Mouse) 231633
osteoblast differentiation
spermatogenesis
biological_process
positive regulation of bone mineralization
biomineral tissue development
positive regulation of osteoblast proliferation
positive regulation of osteoblast differentiation
spermatid differentiation
positive regulation of bone development
ossification
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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