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Invitrogen
TMEM38A Polyclonal Antibody
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Product Details
PA5-20858
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the carboxy terminus of human TMEM38A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat skeletal muscle tissue lysate.
PA5-20858 can be used with blocking peptide PEP-0972.
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 27 kDa sarcoplasmic reticulum protein; Mitsugumin-33A; Mitsugumin33A; sarcoplasmic reticulum protein 27; SPR-27; tmem38a {ECO:0000250|UniProtKB:Q3TMP8}; Transmembrane protein 38A; TRIC-A; TRICA; Trimeric intracellular cation channel type A; unnamed protein product
Gene Aliases: 1110001E17Rik; AI413399; mg33a; RGD1307901; Srp-27; TMEM38A; TRIC-A; TRICA
UniProt ID: (Human) Q9H6F2, (Mouse) Q3TMP8, (Rat) A6ZIQ8
Entrez Gene ID: (Human) 79041, (Mouse) 74166, (Rat) 306327
ion transport
potassium ion transport
endoplasmic reticulum organization
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
ion transmembrane transport
regulation of release of sequestered calcium ion into cytosol
cellular response to caffeine
potassium ion transmembrane transport
inorganic cation transmembrane transport
transport
monovalent inorganic cation transport
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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