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Invitrogen
TMEM38B Polyclonal Antibody
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Product Details
PA5-53809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TMEM38B. Recombinant protein control fragment (Product #RP-91197).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FEDTLSWMLF GWQQPFSSCE KKSEAKSPSN GVGSLASKPV DVASDNV
Highest antigen sequence identity to the following orthologs: Mouse - 53%, Rat - 52%.
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10493; RP11-219P18.1; Transmembrane protein 38B; TRIC-B; Trimeric intracellular cation channel type B; unnamed protein product
Gene Aliases: bA219P18.1; C9orf87; D4Ertd89e; OI14; TMEM38B; TRIC-B; TRICB
UniProt ID: (Human) Q9NVV0
Entrez Gene ID: (Human) 55151
ossification
ion transport
potassium ion transport
endoplasmic reticulum organization
phospholipid biosynthetic process
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
bone mineralization
ion transmembrane transport
lung alveolus development
release of sequestered calcium ion into cytosol
regulation of release of sequestered calcium ion into cytosol
establishment of localization in cell
bone development
lung epithelial cell differentiation
secretion by lung epithelial cell involved in lung growth
extracellular matrix constituent secretion
cellular response to caffeine
potassium ion transmembrane transport
release of sequestered calcium ion into cytosol by endoplasmic reticulum
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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