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FIGURE: 1 / 1
TMEM43 Antibody (PA5-110497) in WB
Western blot analysis of TMEM43 in extracts of various cell lines. Samples were incubated with TMEM43 Polyclonal antibody (Product # PA5-110497) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5s.
Product Details
PA5-110497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 80-310 of human TMEM43 (NP_077310.1).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855908
Product Specific Information
Immunogen sequence: VAPENEGRLV HIIGALRTSK LLSDPNYGVH LPAVKLRRHV EMYQWVETEE SREYTEDGQV KKETRYSYNT EWRSEIINSK NFDREIGHKN PSAMAVESFM ATAPFVQIGR FFLSSGLIDK VDNFKSLSLS KLEDPHVDII RRGDFFYHSE NPKYPEVGDL RVSFSYAGLS GDDPDLGPAH VVTVIARQRG DQLVPFSTKS GDTLLLLHHG DFSAEEVFHR ELRSNSMKTW G
Target Information
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein LUMA; Transmembrane protein 43
Gene Aliases: 1200015A22Rik; ARVC5; ARVD5; EDMD7; LUMA; TMEM43; UNQ2564/PRO6244
UniProt ID: (Human) Q9BTV4, (Mouse) Q9DBS1
Entrez Gene ID: (Human) 79188, (Mouse) 74122
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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